Tramadol is approved for the management of moderate to severe pain in adults.

As an off-label indication, tramadol has been investigated to be used for the treatment of premature ejaculation.

Tramadol, with the chemical formula cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol hydrochloride, is a 4-phenylpiperidine analog of codeine. It is a usual go-to medication as it has less potential for abuse and respiratory depression. Tramadol can be found as 2 enantiomers with active analgesic properties however, the mechanism of action of each of the enantiomers differs greatly. In the FDA records, the first approved tramadol product was developed by Actavis Elizabeth and FDA approved in 2002.